about
Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein InteractionsStructural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic MacrocyclesTernatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold InteractionsDirect comparison of linear and macrocyclic compound libraries as a source of protein ligandsNew Frontiers in DruggabilityPhage-displayed macrocyclic glycopeptide libraries.Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Harnessing C-H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones.Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex MacrocyclesAdvances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Drug discovery beyond the rule of 5 - Opportunities and challenges.Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins.Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acidsModular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams.Harnessing solid-state packing for selective detection of chloride in a macrocyclic anionophore.The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmacBeyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.New Modalities for Challenging Targets in Drug Discovery.Computational solvent mapping in structure-based drug design.Modifying peptides to enhance permeability.Macrocycles All Aflutter: Substitution at an Allylic Center Reveals Conformational Dynamics of [13]-Macrodilactones.Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold-Diverse Macrocyclic LibrariesSystematic Targeting of Protein-Protein InteractionsPeptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.The Performance of Several Docking Programs at Reproducing Protein-Macrolide-Like Crystal Structures.Macrocycles: lessons from the distant past, recent developments, and future directions.Ring-Expansion Reactions in the Synthesis of Macrocycles and Medium-Sized Rings.Structural and conformational determinants of macrocycle cell permeability.The reactivity and conformational control of cyclic tetrapeptides derived from aziridine-containing amino acids.Concise Synthesis of Tetrazole MacrocycleStereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.An efficient method for the in vitro production of azol(in)e-based cyclic peptides.Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
How proteins bind macrocycles.
@ast
How proteins bind macrocycles.
@en
type
label
How proteins bind macrocycles.
@ast
How proteins bind macrocycles.
@en
prefLabel
How proteins bind macrocycles.
@ast
How proteins bind macrocycles.
@en
P2093
P2860
P356
P1476
How proteins bind macrocycles
@en
P2093
Adrian Whitty
Dmitri Beglov
Elizabeth A Villar
John A Porco
Sandor Vajda
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1584
P577
2014-07-20T00:00:00Z