Synthesis and pharmacology of proteasome inhibitors. - Test2 - elhamkhani - TriplyDB

Synthesis and pharmacology of proteasome inhibitors.

Synthesis and pharmacology of proteasome inhibitors.

http://www.wikidata.org/entity/Q38092777

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Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.Development of inhibitors in the ubiquitination cascade.Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.Discovery of new [Formula: see text] proteasome inhibitors using a knowledge-based computational screening approach.A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase.Total Synthesis and Stereochemical Assignment of Nostosin B.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system Pharmacophore modeling technique applied for the discovery of proteasome inhibitors.Recent advances in defining the ubiquitylome.Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents.Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2.The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target α-Boryl isocyanides enable facile preparation of bioactive boropeptides.Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds.Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems.Baceridin, a cyclic hexapeptide from an epiphytic bacillus strain, inhibits the proteasome.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.

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Synthesis and pharmacology of proteasome inhibitors.

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artikel ilmiah

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Synthesis and pharmacology of proteasome inhibitors.

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Synthesis and pharmacology of proteasome inhibitors.

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Synthesis and pharmacology of proteasome inhibitors.

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Angewandte Chemie International Edition

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Synthesis and pharmacology of proteasome inhibitors.

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Andreas Rentsch

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Anna-Katharina Girbig

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Dirk Landsberg

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Leila Bülow

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Markus Kalesse

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Tobias Brodmann

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

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5450-5488

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scholarly article

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10.1002/ANIE.201207900

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21

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52

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2013-03-25T00:00:00Z

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23526565

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