The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. - Test2 - elhamkhani - TriplyDB

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.

http://www.wikidata.org/entity/Q38103448

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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes.The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease.Kynurenine Monooxygenase (KMO) Inhibitors for the Treatment of Acute Pancreatitis and Neurodegenerative Disorders.Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion.Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging

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The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.

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The causative role and therape ...... in neurodegenerative disease.

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The causative role and therape ...... in neurodegenerative disease.

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The causative role and therape ...... in neurodegenerative disease.

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S00109-013-1046-9

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Journal of Molecular Medicine

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The causative role and therape ...... y in neurodegenerative disease

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Flaviano Giorgini

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Nigel S Scrutton

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P2860

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

Cloning and functional expression of human kynurenine 3-monooxygenase

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

Kynurenines in the mammalian brain: when physiology meets pathology

Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

Structural basis of kynurenine 3-monooxygenase inhibition

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Tolerance, DCs and tryptophan: much ado about IDO

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s00109-013-1046-9

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705-713

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scholarly article

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10.1007/S00109-013-1046-9

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6

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91

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Tiago Fleming Outeiro

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2013-05-01T00:00:00Z

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1030176240

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23636512

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neurodegeneration