The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
about
Structural basis of selective ubiquitination of TRF1 by SCFFbx4Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligaseTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationShelterin complex and associated factors at human telomeresPhosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complexNucleostemin delays cellular senescence and negatively regulates TRF1 protein stabilityTelomere and Telomerase Therapeutics in CancerA shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteinsKSHV reactivation and novel implications of protein isomerization on lytic switch controlADP-ribosyltransferases and poly ADP-ribosylationGNL3L stabilizes the TRF1 complex and promotes mitotic transitionPathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegenerationThe Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformationNEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradationDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibilityCullins and cancer.Nucleostemin inhibits TRF1 dimerization and shortens its dynamic association with the telomere.SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy.PinX1: a sought-after major tumor suppressor at human chromosome 8p23Positive and negative regulation of Tetrahymena telomerase holoenzyme.Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding.SCF ubiquitin ligases in the maintenance of genome stability.Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent MechanismsPin1 has opposite effects on wild-type and P301L tau stability and tauopathySmall molecule therapeutics targeting F-box proteins in cancer.Chromatin structure in telomere dynamicsTelomere dynamics: the means to an end.Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.The telosome/shelterin complex and its functions.The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.Telomeric armor: the layers of end protection.Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.
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P2860
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2006 թվականի հունվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
The F-box protein FBX4 targets ...... regulates telomere maintenance
@ast
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en-gb
The F-box protein FBX4 targets ...... regulates telomere maintenance
@nl
type
label
The F-box protein FBX4 targets ...... regulates telomere maintenance
@ast
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en-gb
The F-box protein FBX4 targets ...... regulates telomere maintenance
@nl
prefLabel
The F-box protein FBX4 targets ...... regulates telomere maintenance
@ast
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en-gb
The F-box protein FBX4 targets ...... regulates telomere maintenance
@nl
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P2860
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P1476
The F-box protein FBX4 targets ...... regulates telomere maintenance
@en
P2093
Kilian Perrem
Kun Ping Lu
Tae Ho Lee
Xiao Zhen Zhou
P2860
P304
P3181
P356
10.1074/JBC.M509855200
P407
P577
2005-11-07T00:00:00Z