Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.
about
The organization and contribution of helicases to RNA splicingA noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 proteinPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Mutations in spliceosomal proteins and retina degenerationThe pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.A network biology approach to understanding the importance of chameleon proteins in human physiology and pathology.The determinants of alternative RNA splicing in human cells.Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.Cajal body function in genome organization and transcriptome diversity.Lights, camera, action! Capturing the spliceosome and pre-mRNA splicing with single-molecule fluorescence microscopy.Functions and regulation of the Brr2 RNA helicase during splicing.Utp14 Recruits and Activates the RNA Helicase Dhr1 To Undock U3 snoRNA from the Preribosome.SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.A new role for FBP21 as regulator of Brr2 helicase activity.Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.Synthesis of native-like crosslinked duplex RNA and study of its properties.Variability in clinical phenotypes of PRPF8-linked autosomal dominant retinitis pigmentosa correlates with differential PRPF8/SNRNP200 interactions.Quarterly intrinsic disorder digest (April-May-June, 2014).Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.
P2860
Q26766200-76164107-C673-47EC-8625-F5992ED20E17Q27700104-2D860B8B-F33B-454C-81EE-6DCACE19E4F0Q27937907-386A3199-95FF-4C54-AD1A-8B1BEEC5EAF6Q33739682-931752DA-2135-4864-9846-3D1E825E43E9Q36410173-FEE70E98-9525-4C06-A974-97C69F3481E1Q37065956-E953C2F0-6336-4394-B3D9-72557E3B859AQ37102340-B680875D-CB15-400E-8D55-90F4CE6B324EQ38439978-CD17EA6C-A9EC-454C-A69D-9C2A91D5D86DQ38679766-3AFFAC79-6B55-42C6-AF0F-C9889C044722Q38780090-B572D470-8D8D-4699-BF40-1C0B2473B2DFQ38808242-DCD148A5-3375-44BE-8A19-B8514494A81CQ38838948-1EAD7101-A43D-4102-9A01-F469FD832C91Q38993788-6C84A56F-CCC2-44B8-8634-3E520266311FQ39596728-69C9989F-343F-4CAE-A815-6123A41783E6Q40950182-DB3F342F-055B-4B20-8BA9-9164E0320651Q41310559-A6925EA9-D696-4D1B-A75D-9AEC1EF2EC4FQ41510811-EF370E9C-A359-4181-8C65-15379E9441B5Q42687222-891FEF8F-AC41-42DE-AA13-0A10EAD5741DQ45765008-961E5D9F-45E7-4909-B076-31E73CD1AA05Q46128546-6947459A-EE03-43CD-A926-CA6985AC1324Q47583754-B52462DE-C83D-459D-BBF6-4A758A36F2E4Q50787059-89C01427-2C9E-4404-8824-100AE2B7E335Q52371537-2BBC8A94-711A-4F43-A7F9-290154E887EF
P2860
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Novel regulatory principles of ...... to retinal disease in humans.
@en
type
label
Novel regulatory principles of ...... to retinal disease in humans.
@en
prefLabel
Novel regulatory principles of ...... to retinal disease in humans.
@en
P2860
P50
P356
P1433
P1476
Novel regulatory principles of ...... to retinal disease in humans.
@en
P2093
Karine F Santos
Traudy Wandersleben
P2860
P304
P356
10.4161/RNA.28353
P577
2014-03-05T00:00:00Z