Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

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Production of proteasome inhibitor syringolin A by the endophyte Rhizobium sp. strain AP16.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.

P2860

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Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

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http://www.wikidata.org/entity/Q38266742

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2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

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2011年學術文章

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name

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

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type

Item

label

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

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prefLabel

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

@en

P1476

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

@en

P2093

Christopher T Walsh

http://www.w3.org/2001/XMLSchema#string

Daniel Krahn

http://www.w3.org/2001/XMLSchema#string

Markus Kaiser

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily.

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

A new enzyme superfamily - the phosphopantetheinyl transferases

Biosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate.

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Proteasome inhibitors in cancer therapy: lessons from the first decade.

Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma.

Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines.

SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A.

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4518-4521

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scholarly article

P356

10.1021/OL2016687

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English

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P478

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William M. Wuest

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2011-08-03T00:00:00Z

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51543384

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21812451

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P932

3163001

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Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

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P2860

P2860

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932