Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein. - Test2 - elhamkhani - TriplyDB

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

http://www.wikidata.org/entity/Q38358131

about

New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1 Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity Overexpression of Fli-1 in astrocytoma is associated with poor prognosis.Phase I dose-escalating study of panobinostat (LBH589) administered intravenously to Japanese patients with advanced solid tumors.The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function Protein disorder in the human diseasome: unfoldomics of human genetic diseases.Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin.Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.Promiscuous partnerships in Ewing's sarcoma.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL The biology of ewing sarcoma Recent advances in the molecular pathogenesis of Ewing's sarcoma.Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.Inhibition of histone acetyltransferase by glycosaminoglycans EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells.EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Molecular abnormalities in Ewing's sarcoma.Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review.Anti-Epileptic Drug Targets Ewing Sarcoma.The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.RUNX3 facilitates growth of Ewing sarcoma cells

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Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

http://www.wikidata.org/entity/Q38358131

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

@en

type

label

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

@en

prefLabel

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

@en

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Journal of Biological Chemistry

P1476

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.

@en

P2093

Fumihiko Nakatani

http://www.w3.org/2001/XMLSchema#string

Kazuhiro Tanaka

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Masuo Hanada

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Riku Sakimura

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Takamitsu Okada

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Tomoya Matsunobu

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Xu Li

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Yoshihiro Matsumoto

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Yukihide Iwamoto

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P2860

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The transcriptional coactivators p300 and CBP are histone acetyltransferases

CDK inhibitors: positive and negative regulators of G1-phase progression

WAF1, a potential mediator of p53 tumor suppression

The CBP co-activator is a histone acetyltransferase

Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion

Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression

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15105-15115

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scholarly article

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10.1074/JBC.M211470200

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P433

17

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278

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2003-01-30T00:00:00Z

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12560328

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