Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
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New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancerCD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesisThe effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependentα-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activityOverexpression of Fli-1 in astrocytoma is associated with poor prognosis.Phase I dose-escalating study of panobinostat (LBH589) administered intravenously to Japanese patients with advanced solid tumors.The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation functionProtein disorder in the human diseasome: unfoldomics of human genetic diseases.Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisEWS-FLI1 target genes recovered from Ewing's sarcoma chromatin.Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.Promiscuous partnerships in Ewing's sarcoma.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKLThe biology of ewing sarcomaRecent advances in the molecular pathogenesis of Ewing's sarcoma.Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma CellsOncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.Inhibition of histone acetyltransferase by glycosaminoglycansEWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells.EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcomaSystems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Molecular abnormalities in Ewing's sarcoma.Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review.Anti-Epileptic Drug Targets Ewing Sarcoma.The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.RUNX3 facilitates growth of Ewing sarcoma cells
P2860
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P2860
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
@en
type
label
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
@en
prefLabel
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
@en
P2093
P2860
P356
P1476
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
@en
P2093
Fumihiko Nakatani
Kazuhiro Tanaka
Masuo Hanada
Riku Sakimura
Takamitsu Okada
Tomoya Matsunobu
Yoshihiro Matsumoto
Yukihide Iwamoto
P2860
P304
15105-15115
P356
10.1074/JBC.M211470200
P407
P577
2003-01-30T00:00:00Z