Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

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http://www.wikidata.org/entity/Q38444354
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disordersMitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens.Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria.Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.Biased agonism: An emerging paradigm in GPCR drug discovery.Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Biased signalling: from simple switches to allosteric microprocessors.Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice.Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors.Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity
P2860

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

Item
http://www.wikidata.org/entity/Q38444354
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Structure-activity relationshi ...... ver βarrestin2 signaling bias.
@en
type
label
Structure-activity relationshi ...... ver βarrestin2 signaling bias.
@en
prefLabel
Structure-activity relationshi ...... ver βarrestin2 signaling bias.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Structure-activity relationshi ...... ver βarrestin2 signaling bias.
@en
P2093
P2860
P304
P31
P356
10.1021/ACSCHEMNEURO.5B00092
P433
P478
P50
P577
P698
P921
P932