Discovery of microbial natural products by activation of silent biosynthetic gene clusters.
about
Accessing Nature's diversity through metabolic engineering and synthetic biologyDiscovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes.The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine MicroorganismsHuman commensals producing a novel antibiotic impair pathogen colonizationPredominately Uncultured Microbes as Sources of Bioactive AgentsBacteriocins of lactic acid bacteria: extending the familySynthetic biology to access and expand nature's chemical diversityGut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme PeroxidasesEndless Resistance. Endless Antibiotics?Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides.Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning.Discovery of MRSA active antibiotics using primary sequence from the human microbiome.Natural products as mediators of disease.Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites.Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D.Using natural products for drug discovery: the impact of the genomics era.plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clustersIsolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2.Taxonomy, Physiology, and Natural Products of Actinobacteria.New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome MiningCharacterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivativeTargeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid DiagnosticsAntibiotic discovery is a walk in the park.IMG-ABC: new features for bacterial secondary metabolism analysis and targeted biosynthetic gene cluster discovery in thousands of microbial genomes.Identification of a Novel Lincomycin Resistance Mutation Associated with Activation of Antibiotic Production in Streptomyces coelicolor A3(2).Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2).Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens.Bioactive natural products from novel microbial sources.Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Microbiome and metabolome data integration provides insight into health and disease.Induction of Cryptic and Bioactive Metabolites through Natural Dietary Components in an Endophytic Fungus Colletotrichum gloeosporioides (Penz.) SaccGenome-Wide Analysis of Secondary Metabolite Gene Clusters in Ophiostoma ulmi and Ophiostoma novo-ulmi Reveals a Fujikurin-Like Gene Cluster with a Putative Role in Infection.Probiotic Enterococcus mundtii Isolate Protects the Model Insect Tribolium castaneum against Bacillus thuringiensis.The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation in Streptomyces venezuelae NRRL B-65442.Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry.Retrospective analysis of natural products provides insights for future discovery trends.The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin.
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Discovery of microbial natural products by activation of silent biosynthetic gene clusters.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Discovery of microbial natural ...... nt biosynthetic gene clusters.
@en
type
label
Discovery of microbial natural ...... nt biosynthetic gene clusters.
@en
prefLabel
Discovery of microbial natural ...... nt biosynthetic gene clusters.
@en
P2860
P356
P1476
Discovery of microbial natural ...... nt biosynthetic gene clusters.
@en
P2093
Peter J Rutledge
P2860
P2888
P304
P356
10.1038/NRMICRO3496
P407
P577
2015-06-29T00:00:00Z
P6179
1030342017