about
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamateDiscovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasisTheonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactionsDevelopment of FXR, PXR and CAR agonists and antagonists for treatment of liver disordersThe bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammationNew isomalabaricane derivatives from a new species of Jaspis sponge collected at the Vanuatu islands.Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulationTheonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensisStructures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activityFarnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.Marine sponge steroids as nuclear receptor ligands.Perthamide C inhibits eNOS and iNOS expression and has immunomodulating activity in vivo.Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.Role of nuclear receptors in lipid dysfunction and obesity-related diseases.Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.Natural ligands for nuclear receptors: biology and potential therapeutic applications.Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application.Farnesoid X receptor modulators (2011 - 2014): a patent review.New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei.Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity.Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts.Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei.Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei.Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.
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P50
description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
@hy
name
Angela Zampella
@ast
Angela Zampella
@en
Angela Zampella
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Angela Zampella
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type
label
Angela Zampella
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Angela Zampella
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Angela Zampella
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Angela Zampella
@nl
prefLabel
Angela Zampella
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Angela Zampella
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Angela Zampella
@es
Angela Zampella
@nl
P106
P1153
6603938054
P21
P2798
P31
P496
0000-0002-6170-279X