Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
about
Next-generation antimicrobials: from chemical biology to first-in-class drugsInhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and HydrazidesSelective small-molecule inhibition of an RNA structural elementTarget-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.Essential genome of Pseudomonas aeruginosa in cystic fibrosis sputum.Horizontally Acquired Biosynthesis Genes Boost Coxiella burnetii's Physiology.Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context.Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.Untargeted Metabolomics To Ascertain Antibiotic Modes of Action.Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.Unconventional screening approaches for antibiotic discovery.Strategies for target identification of antimicrobial natural products.A robust platform for chemical genomics in bacterial systems.The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli.Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.Opportunities for natural products in 21st century antibiotic discovery.Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.Drug discovery: Leaving no stone unturned.Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells.Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-β-lactam.8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.Integrated Metabolomics and Morphogenesis Reveals Volatile Signaling of the Nematode-Trapping Fungus Arthrobotrys oligospora.Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.Vitamin Biosynthesis as an Antifungal Target.Novel small molecules affecting cell membrane as potential therapeutics for avian pathogenic Escherichia coliHigh-Throughput Screening of Biodiversity for Antibiotic Discovery
P2860
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P2860
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
@en
type
label
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
@en
prefLabel
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
@en
P2093
P2860
P356
P1476
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.
@en
P2093
Eric D Brown
Lauren F Ferruccio
Soumaya Zlitni
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1361
P577
2013-10-13T00:00:00Z
P5875
P6179
1035068060