Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

about

Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer

P2860

Q50316561-9FFFAA67-7C43-475D-983A-B99F2441EA01 Q58542910-5F7844AE-74B6-454E-BD13-36BED7CBD8BE

P2860

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

Item

http://www.wikidata.org/entity/Q38723764

description

2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

@en

type

Item

label

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

@en

prefLabel

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

@en

P1476

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

@en

P2093

Mu-Shui Dai

http://www.w3.org/2001/XMLSchema#string

Xiao-Xin Sun

http://www.w3.org/2001/XMLSchema#string

Yingxiao Chen

http://www.w3.org/2001/XMLSchema#string

Yue-Gang Wang

http://www.w3.org/2001/XMLSchema#string

Yuhuang Li

http://www.w3.org/2001/XMLSchema#string

P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

p53 has a direct apoptogenic role at the mitochondria

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

P304

11053-11062

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.18632/ONCOTARGET.14278

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2016-12-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28035068

http://www.w3.org/2001/XMLSchema#string

P932

5355245

http://www.w3.org/2001/XMLSchema#string

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

about

P2860

P2860

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P932