about
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cellsPML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0In memoriam--Richard M. Elliott (1954-2015)A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responsesHSV-1 ICP0: paving the way for viral replicationA RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defenceGenetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins.The herpes simplex virus triplex protein, VP23, exists as a molten globule.Host and viral determinants of Mx2 antiretroviral activityThe intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes.A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitroViral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain.Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3 ubiquitin ligase activity of ICP0 in a cell type-dependent manner.Sequences related to SUMO interaction motifs in herpes simplex virus 1 protein ICP0 act cooperatively to stimulate virus infectionRegulation of alphaherpesvirus infections by the ICP0 family of proteins.Interplay between viruses and host sumoylation pathways.Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response.Depletion of intracellular zinc inhibits the ubiquitin ligase activity of viral regulatory protein ICP0 and restricts herpes simplex virus 1 replication in cell culture.Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligaseHerpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro.The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome.Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome.Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner.Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0.SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1.Functional characterization of residues required for the herpes simplex virus 1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a)The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0.New regulators of the BRCA1 response to genotoxic stress.Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.Correction: Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infectionCENP-B dynamics at centromeres is regulated by a SUMOylation/ubiquitination and proteasomal-dependent degradation mechanism involving the SUMO-targeted ubiquitin E3 ligase RNF4
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Chris Boutell
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Chris Boutell
@en
Chris Boutell
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Chris Boutell
@nl
Chris Boutell
@sl
type
label
Chris Boutell
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Chris Boutell
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Chris Boutell
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Chris Boutell
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Chris Boutell
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prefLabel
Chris Boutell
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Chris Boutell
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Chris Boutell
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Chris Boutell
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Chris Boutell
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P106
P21
P31
P3835
chris-boutell
P496
0000-0002-2970-7785