Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. - Test2 - elhamkhani - TriplyDB

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

http://www.wikidata.org/entity/Q33231274

about

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm A guide for functional analysis of BRCA1 variants of uncertain significance The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.Assessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.The UPS: a promising target for breast cancer treatment.BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development.BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility.Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis.Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.DNA double-strand break signaling and human disorders.Functional differences among BRCA1 missense mutations in the control of centrosome duplication Characterization of BRCA1 ring finger variants of uncertain significance Characterization of an Italian founder mutation in the RING-finger domain of BRCA1.The BRCA1 variant p.Ser36Tyr abrogates BRCA1 protein function and potentially confers a moderate risk of breast cancer.BRCA1 Circos: a visualisation resource for functional analysis of missense variants.In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein.Description and analysis of genetic variants in French hereditary breast and ovarian cancer families recorded in the UMD-BRCA1/BRCA2 databases.Functional assays for BRCA1 and BRCA2.Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.BRCA1 tumor suppressor network: focusing on its tail.A DNA repair BRCA1 estrogen receptor and targeted therapy in breast cancer.A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes The Association between GWAS-identified BARD1 Gene SNPs and Neuroblastoma Susceptibility in a Southern Chinese Population.RNF111-dependent neddylation activates DNA damage-induced ubiquitination.BRCA1 in the DNA damage response and at telomeres Assessment of functional effects of unclassified genetic variants.The Clinical Significance of Unknown Sequence Variants in BRCA Genes.Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis.Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation.Analysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing.More modifiers move on DNA damage.Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand Breaks Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.The BRCA1 ubiquitin ligase and homologous recombination repair.A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer.

P2860

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P2860

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

http://www.wikidata.org/entity/Q33231274

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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type

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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Human Molecular Genetics

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Genetic analysis of BRCA1 ubiq ...... breast cancer susceptibility.

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P2093

Ellen Solomon

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Joanna R Morris

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Laurent Pangon

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Toyomasa Katagiri

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P2860

BRCA1 participates in DNA decatenation

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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599-606

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scholarly article

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10.1093/HMG/DDI476

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4

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15

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Nicholas H. Keep

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2006-01-10T00:00:00Z

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7367824

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