The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.
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Systemic VHL gene functions and the VHL diseaseRegulation of human metabolism by hypoxia-inducible factorCardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutationMolecular pathogenesis of pulmonary arterial hypertensionHIF hydroxylase pathways in cardiovascular physiology and medicineDefective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensingThe physiological functions of iron regulatory proteins in iron homeostasis - an update.Inflammation and immunity in the pathogenesis of pulmonary arterial hypertensionHIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolismLoss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritisHuman high-altitude adaptation: forward genetics meets the HIF pathway.VHL, the story of a tumour suppressor gene.Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne Muscular Dystrophy (DMD).The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia.Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans.Mitochondrial dynamics in pulmonary arterial hypertension.Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosisIncreased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertensionPulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).Anaemia in kidney disease: harnessing hypoxia responses for therapyComplex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema.Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.High levels of zinc-protoporphyrin identify iron metabolic abnormalities in pulmonary arterial hypertension.The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutationProlyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α.Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1α and hypoxia-inducible transcription factor-2α.Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver diseasePulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives.HIF and pulmonary vascular responses to hypoxia.The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxiaHuman adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.
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P2860
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@en
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@nl
type
label
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@en
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@nl
prefLabel
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@en
The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.
@nl
P2093
P2860
P356
P1476
The von Hippel-Lindau Chuvash ...... ertension and fibrosis in mice
@en
P2093
Charalambos C Solomides
Edward E Morrisey
Evguenia Arguiri
Hongwei Yu
M Celeste Simon
Melpo Christofidou-Solomidou
Michele M Hickey
Qian-Chun Yu
Tejvir S Khurana
P2860
P304
P356
10.1172/JCI36362
P407
P577
2010-02-08T00:00:00Z