The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. - Test2 - elhamkhani - TriplyDB

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

http://www.wikidata.org/entity/Q39250750

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Systemic VHL gene functions and the VHL disease Regulation of human metabolism by hypoxia-inducible factor Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation Molecular pathogenesis of pulmonary arterial hypertension HIF hydroxylase pathways in cardiovascular physiology and medicine Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing The physiological functions of iron regulatory proteins in iron homeostasis - an update.Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis Human high-altitude adaptation: forward genetics meets the HIF pathway.VHL, the story of a tumour suppressor gene.Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne Muscular Dystrophy (DMD).The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia.Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans.Mitochondrial dynamics in pulmonary arterial hypertension.Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).Anaemia in kidney disease: harnessing hypoxia responses for therapy Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema.Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.High levels of zinc-protoporphyrin identify iron metabolic abnormalities in pulmonary arterial hypertension.The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α.Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1α and hypoxia-inducible transcription factor-2α.Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives.HIF and pulmonary vascular responses to hypoxia.The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.

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The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

http://www.wikidata.org/entity/Q39250750

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2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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type

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The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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The von Hippel-Lindau Chuvash ...... rtension and fibrosis in mice.

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Journal of Clinical Investigation

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The von Hippel-Lindau Chuvash ...... ertension and fibrosis in mice

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Charalambos C Solomides

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Edward E Morrisey

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Evguenia Arguiri

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Hongwei Yu

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M Celeste Simon

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Melpo Christofidou-Solomidou

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Michele M Hickey

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Qian-Chun Yu

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Tao Wang

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Tejvir S Khurana

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

Targeting HIF-1 for cancer therapy

Vascular complications in Chuvash polycythemia

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

Molecular basis of the VHL hereditary cancer syndrome

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3

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Matias Mosqueira

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2010-02-08T00:00:00Z

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20197624

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arterial hypertension

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2827942

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