VHL, the story of a tumour suppressor gene. - Test2 - elhamkhani - TriplyDB

VHL, the story of a tumour suppressor gene.

VHL, the story of a tumour suppressor gene.

http://www.wikidata.org/entity/Q34455226

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Sequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspective Wnt Signaling in Renal Cell Carcinoma Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis Therapeutic challenges in renal cell carcinoma Medical treatment of renal cancer: new horizons The ever-expanding role of HIF in tumour and stromal biology Dysregulation of ubiquitin ligases in cancer Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Loss of Quiescence in von Hippel-Lindau Hemangioblastomas is Associated with Erythropoietin Signaling.Expert Recommendations for First-Line Management of Metastatic Renal Cell Carcinoma in Special Subpopulations.Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure.RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program.Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2.Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer.Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma.Genotype-phenotype analysis of von Hippel-Lindau syndrome in Korean families: HIF-α binding site missense mutations elevate age-specific risk for CNS hemangioblastoma HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma.Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC).Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model.Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia WSB1 promotes tumor metastasis by inducing pVHL degradation Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2 The multifaceted role of autophagy in tumor evasion from immune surveillance VHLdb: A database of von Hippel-Lindau protein interactors and mutations.Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease USP9X destabilizes pVHL and promotes cell proliferation.pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer.Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability.HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma.

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VHL, the story of a tumour suppressor gene.

http://www.wikidata.org/entity/Q34455226

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2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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VHL, the story of a tumour suppressor gene.

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VHL, the story of a tumour suppressor gene.

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VHL, the story of a tumour suppressor gene.

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Nature Reviews Cancer

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VHL, the story of a tumour suppressor gene.

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Eamonn R Maher

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Lucy Gossage

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Tim Eisen

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P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

A conserved family of prolyl-4-hydroxylases that modify HIF

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Inhibition of transcription elongation by the VHL tumor suppressor protein

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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