Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
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FAK in cancer: mechanistic findings and clinical applicationsBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial CellsThe oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitorSMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathwayThe marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyHIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction.Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine TumorsProtein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Disease PathologyHistone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix.PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
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Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@en
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@nl
type
label
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@en
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@nl
prefLabel
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@en
Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@nl
P2093
P2860
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Protein tyrosine kinase 6 prot ...... ion kinase and activating AKT.
@en
P2093
P2860
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P304
P356
10.1038/ONC.2012.427
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P577
2012-10-01T00:00:00Z
P5875
P6179
1029198198