Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric DisordersThe associations between Parkinson's disease and cancer: the plot thickensImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersSeeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortexPost translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.CSF proteins and resting-state functional connectivity in Parkinson disease.Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviourPoststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders.Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.Calcium signaling in Parkinson's disease.Protein phosphorylation in neurodegeneration: friend or foe?Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.Models of α-synuclein aggregation in Parkinson's disease.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Mini review: linkage between α-Synuclein protein and cognition.Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous roleStructure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Investigational α-synuclein aggregation inhibitors: hope for Parkinson's disease.Early synaptic dysfunction in Parkinson's disease: Insights from animal models.Alpha-synuclein modulates dopamine neurotransmission.(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivoThe small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.Preparation of neuronal co-cultures with single cell precisionSynucleinopathies: common features and hippocampal manifestations.Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.Designer protein disaggregases to counter neurodegenerative disease.Synaptoimmunology - roles in health and disease.Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.
P2860
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P2860
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@en
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@nl
type
label
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@en
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@nl
prefLabel
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@en
Extracellular alpha-synuclein ...... via NMDA-receptor activation.
@nl
P2093
P50
P1476
Extracellular alpha-synuclein ...... P via NMDA-receptor activation
@en
P2093
Francesca Maiolino
Joakim Bergström
Lars Lannfelt
Thomas Näsström
P304
11750-11762
P356
10.1523/JNEUROSCI.0234-12.2012
P407
P50
P577
2012-08-01T00:00:00Z