Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.
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Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Current views on the potential for development of a HIV vaccine.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman PrimatesExploiting Natural Cross-reactivity between Human Immunodeficiency Virus (HIV)-1 p17 Protein and Anti-gp41 2F5 Antibody to Induce HIV-1 Neutralizing Responses In Vivo.Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens.Progress toward active or passive HIV-1 vaccination.Profiling the neutralizing antibody response in chronically HIV-1 CRF07_BC-infected intravenous drug users naïve to antiretroviral therapy.Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.Germline-targeting immunogens.Genetic and structural analyses of affinity maturation in the humoral response to HIV-1.Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.Identification and specificity of broadly neutralizing antibodies against HIVHow HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design.Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer.Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins.Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.The quest for an antibody-based HIV vaccine.Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development.The 2017 Keystone Symposium on HIV Vaccines.Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity.HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage.Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.EDiP: the Epitope Dilution Phenomenon. Lessons learnt from a malaria vaccine antigen and its applicability to polymorphic antigens.Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses.Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.Developing an HIV vaccine.Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing.
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P2860
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@en
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@nl
type
label
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@en
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@nl
prefLabel
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@en
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@nl
P2093
P2860
P50
P1433
P1476
Sequential Immunization Elicit ...... Antibodies in Ig Knockin Mice.
@en
P2093
Alexander D Gitlin
Amelia Escolano
Anna Gazumyan
Daniel W Kulp
Dennis R Burton
Erik Georgeson
Jennifer Heinemann
Jon M Steichen
Jovana Golijanin
P2860
P304
1445-1458.e12
P356
10.1016/J.CELL.2016.07.030
P407
P577
2016-09-01T00:00:00Z