Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.
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Exploring anti-bacterial compounds against intracellular LegionellaCellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated ProteinsIndividual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles.Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging.Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.Boron-based inhibitors of acyl protein thioesterases 1 and 2.Target identification for small bioactive molecules: finding the needle in the haystack.Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolasesAcyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.Small-molecule modulation of Ras signaling.Targeting oncogenic Ras signaling in hematologic malignancies.Profiling and inhibiting reversible palmitoylationFat chance! Getting a grip on a slippery modification.Targeting protein palmitoylation: selective inhibitors and implications in disease.Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Current status of the development of Ras inhibitors.Pharmacological Inhibition of Protein Lipidation.Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin.Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.Multiexcitation Fluorogenic Labeling of Surface, Intracellular, and Total Protein Pools in Living Cells.The mechanism of caseinolytic protease (ClpP) inhibition.Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.Posttranslational Modifications of RAS Proteins.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Protein depalmitoylases.Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery.Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.
P2860
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P2860
Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Development of highly potent i ...... n substrate similarity design.
@en
Development of highly potent i ...... n substrate similarity design.
@en-gb
Development of highly potent i ...... n substrate similarity design.
@nl
type
label
Development of highly potent i ...... n substrate similarity design.
@en
Development of highly potent i ...... n substrate similarity design.
@en-gb
Development of highly potent i ...... n substrate similarity design.
@nl
prefLabel
Development of highly potent i ...... n substrate similarity design.
@en
Development of highly potent i ...... n substrate similarity design.
@en-gb
Development of highly potent i ...... n substrate similarity design.
@nl
P2093
P2860
P50
P356
P1476
Development of highly potent i ...... n substrate similarity design.
@en
P2093
Christian Hedberg
Claas Gerding-Reimers
Marion Rusch
Nachiket Vartak
Philippe I H Bastiaens
Stefan Wetzel
Steffen Renner
P2860
P304
P356
10.1002/ANIE.201102965
P407
P577
2011-09-09T00:00:00Z