Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization.
about
A novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compoundsHemozoin and antimalarial drug discoveryIdentification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strainsUnsaturated glycerophospholipids mediate heme crystallization: biological implications for hemozoin formation in the kissing bug Rhodnius prolixusOptimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.Insights into the role of heme in the mechanism of action of antimalarials.Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration.4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle.Novel carbazole aminoalcohols as inhibitors of β-hematin formation: Antiplasmodial and antischistosomal activities.Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds.Antiplasmodial drug targets: a patent review (2000 - 2013).Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics.Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes.High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic compositionDeconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors.Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated β-Hematin Crystallization.Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum.Polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis.Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets.Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.Prediction model for anti-malarial activities of hemozoin inhibitors using physicochemical properties.Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates
P2860
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P2860
Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@en
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@nl
type
label
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@en
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@nl
prefLabel
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@en
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@nl
P2093
P2860
P356
P1476
Use of the NP-40 detergent-med ...... beta-hematin crystallization.
@en
P2093
David W Wright
Jacob D Johnson
Jennifer M Auschwitz
Melissa D Carter
Patricia J Lee
Rebecca D Sandlin
Susan E Leed
P2860
P304
P356
10.1128/AAC.00121-11
P407
P577
2011-04-25T00:00:00Z