Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
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Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesBiosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferaseMycobacterium tuberculosis proteins involved in mycolic acid synthesis and transport localize dynamically to the old growing pole and septumCrystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by ThiolactomycinStructural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisPpm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteriaThe missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosisAccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosisIdentification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosisDeletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent miceThe condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylationMycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulenceIdentification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatisIdentification of KasA as the cellular target of an anti-tubercular scaffoldMycoperonDB: a database of computationally identified operons and transcriptional units in Mycobacteria.Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.Involvement of two latex-clearing proteins during rubber degradation and insights into the subsequent degradation pathway revealed by the genome sequence of Gordonia polyisoprenivorans strain VH2Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival.Regulated Expression Systems for Mycobacteria and Their ApplicationsFunctional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabGNew approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.Targeting the formation of the cell wall core of M. tuberculosis.Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis.Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium.Fatty acid biosynthesis in actinomycetes.Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillusElucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strainIn Silico Drug Design of Thiolactomycin Derivatives Against Mtb-KasA Enzyme to Inhibit Multidrug Resistance of Mycobacterium tuberculosis.The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence.A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability.Role of long-chain acyl-CoAs in the regulation of mycolic acid biosynthesis in mycobacteria.Substrate recognition by β-ketoacyl-ACP synthases.
P2860
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P2860
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@en
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@nl
type
label
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@en
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@nl
prefLabel
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@en
Conditional depletion of KasA, ...... s to mycobacterial cell lysis.
@nl
P2093
P2860
P1476
Conditional depletion of KasA, ...... ds to mycobacterial cell lysis
@en
P2093
Annie Z Dai
Apoorva Bhatt
James C Sacchettini
P2860
P304
P356
10.1128/JB.187.22.7596-7606.2005
P407
P577
2005-11-01T00:00:00Z