Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
about
Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanismMetabolic modulation of chromatin: implications for DNA repair and genomic integrityPhosphorylation of epigenetic "readers, writers and erasers": Implications for developmental reprogramming and the epigenetic basis for health and diseaseHijacked in cancer: the KMT2 (MLL) family of methyltransferasesThe effect of the intra-S-phase checkpoint on origins of replication in human cells.Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells.Likelihood-Based Approach to Gene Set Enrichment Analysis with a Finite Mixture ModelZebrafish mll gene is essential for hematopoiesis.A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growthTrithorax group proteins: switching genes on and keeping them active.Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemiaH3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firingA DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency.Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATRECSASB2 mediates MLL degradation during hematopoietic differentiationThe pathogenesis of mixed-lineage leukemia.Cell cycle control in acute myeloid leukemia.Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo.MLL1 is essential for the senescence-associated secretory phenotypeATR signalling: more than meeting at the fork.HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.An MLL-dependent network sustains hematopoiesis.Effectiveness of AMD3100 in treatment of leukemia and solid tumors: from original discovery to use in current clinical practice.PUMA and BIM are required for oncogene inactivation-induced apoptosis.SET for life: biochemical activities and biological functions of SET domain-containing proteinsATR: a master conductor of cellular responses to DNA replication stress.Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control.Histone onco-modifications.Epigenetics and B-cell lymphoma.Glioma stem cell maintenance: the role of the microenvironment.Genetic variation and DNA replication timing, or why is there late replicating DNA?Emerging roles for chromatin as a signal integration and storage platform.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesMolecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.
P2860
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P2860
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@en
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@nl
type
label
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@en
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@nl
prefLabel
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@en
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@nl
P2093
P2860
P356
P1433
P1476
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
@en
P2093
Emily H-Y Cheng
Eric J Brown
James J-D Hsieh
Rakesh Kumar
Shugaku Takeda
Tej K Pandita
Todd D Westergard
P2860
P2888
P304
P356
10.1038/NATURE09350
P407
P577
2010-09-05T00:00:00Z
P5875
P6179
1021177784