ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
about
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisChk2 activation dependence on Nbs1 after DNA damageMre11 complex and DNA replication: linkage to E2F and sites of DNA synthesisSMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointCritical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2AMSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylationThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayATM-dependent phosphorylation of ATF2 is required for the DNA damage responseThe tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complexHighlight: BRCA1 and BRCA2 proteins in breast cancerMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairSIRT1 regulates the function of the Nijmegen breakage syndrome proteinTargeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53Regulation of TIP60 by ATF2 modulates ATM activationThe mismatch repair system is required for S-phase checkpoint activationUV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationChk1 and p21 cooperate to prevent apoptosis during DNA replication fork stressDisruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damageATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localizationEarly embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during developmentFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damageMinichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesMultiple roles of ATM in monitoring and maintaining DNA integrityC. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpointDirect DNA binding by Brca1Immunoglobulin class switch recombination is impaired in Atm-deficient miceInvolvement of nucleotide excision and mismatch repair mechanisms in double strand break repairThe combined status of ATM and p53 link tumor development with therapeutic responseEnhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsMolecular pathology of ataxia telangiectasiaInvolvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageCdc7-Dbf4 and the human S checkpoint response to UVC
P2860
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P2860
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@ast
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en-gb
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@nl
type
label
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@ast
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en-gb
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@nl
prefLabel
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@ast
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en-gb
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@nl
P2093
P921
P3181
P356
P1433
P1476
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
@en
P2093
J H Petrini
M B Kastan
P2888
P3181
P356
10.1038/35007091
P407
P577
2000-04-06T00:00:00Z
P5875
P6179
1007927189