The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.
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Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongationStructure and function of a HECT domain ubiquitin-binding siteStructure of the HECT C-lobe of the UBR5 E3 ubiquitin ligaseMechanism of ubiquitin ligation and lysine prioritization by a HECT E3E2s: structurally economical and functionally repleteActivation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnoverUSP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selectionDevelopment of inhibitors in the ubiquitination cascade.Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitinationThe Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases.SMURF and NEDD4: sharp shooters monitor the gate keepers and ion traffic controllers of lead astray cell.Role of Smad signaling in kidney disease.Dynamic ubiquitin signaling in cell cycle regulation.The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.A conformational switch regulates the ubiquitin ligase HUWE1.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.A Tunable Brake for HECT Ubiquitin Ligases.
P2860
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P2860
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.
description
2009 nî lūn-bûn
@nan
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
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2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
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2009年學術文章
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name
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@en
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@nl
type
label
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@en
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@nl
prefLabel
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@en
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@nl
P2093
P2860
P50
P356
P1476
The ubiquitin binding region o ...... g of ubiquitylated substrates.
@en
P2093
Abiodun A Ogunjimi
Douglas J Briant
Frank Sicheri
Jeffrey L Wrana
P2860
P304
P356
10.1074/JBC.M109.044537
P407
P577
2009-12-21T00:00:00Z