The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.
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Protein lysine acetylation by p300/CBPNaphthyridines as novel BET family bromodomain inhibitorsStructure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain InhibitorsDiscovery and optimization of small-molecule ligands for the CBP/p300 bromodomainsTargeting BET bromodomains for cancer treatmentBET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Drug Discovery Targeting Bromodomain-Containing Protein 4.BET inhibition as a new strategy for the treatment of gastric cancer.Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3.A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.Pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation for the discovery of novel BRD4 inhibitors.Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomainsDiscovery of BET bromodomain inhibitors and their role in target validationDirect photocapture of bromodomains using tropolone chemical probes
P2860
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P2860
The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The design and synthesis of 5- ...... itors of the BET bromodomains.
@en
type
label
The design and synthesis of 5- ...... itors of the BET bromodomains.
@en
prefLabel
The design and synthesis of 5- ...... itors of the BET bromodomains.
@en
P2093
P2860
P50
P356
P1433
P1476
The design and synthesis of 5- ...... itors of the BET bromodomains.
@en
P2093
Duncan Hay
Martin Philpott
Sagar Uttakar
Sarah Martin
Sarah Picaud
Tom D Heightman
P2860
P304
P356
10.1039/C2MD20189E
P577
2013-01-01T00:00:00Z