Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
about
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entryAcidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cellsTMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinA Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous SystemsThe transmembrane domain of TACE regulates protein ectodomain sheddingCharacterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cellsNew perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failureProteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidenceTranslation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNATargeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension.Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiologyFrom gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertensionDetection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone systemA functional role for ADAM10 in human immunodeficiency virus type-1 replicationThe renin angiotensin system and the metabolic syndromeUpregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway.Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans.Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes.The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulinAngiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin II type I receptor-dependent mechanism.Rosiglitazone treatment of type 2 diabetic db/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretionACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injuryTargeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failureACE and ACE2 in kidney diseaseSoluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.Angiotensin-converting enzyme 2: the first decade.Functional and molecular evidence for expression of the renin angiotensin system and ADAM17-mediated ACE2 shedding in COS7 cellsCirculating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease.Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling.Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension.Angiotensin converting enzyme 2: a new important player in the regulation of glycemia.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease.Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice.SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry
P2860
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P2860
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en-gb
type
label
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en-gb
prefLabel
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en-gb
P2093
P2860
P356
P1476
Tumor necrosis factor-alpha co ...... in-converting enzyme-2 (ACE2).
@en
P2093
A Ian Smith
Anthony J Turner
Daniel W Lambert
Fiona J Warner
Mike Yarski
Paul Thornhill
P2860
P304
30113-30119
P356
10.1074/JBC.M505111200
P407
P577
2005-06-27T00:00:00Z