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T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionMYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteinsIdentification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPaseTrafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domainAn ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary ciliumABL tyrosine kinases: evolution of function, regulation, and specificityAllosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1ELM: the status of the 2010 eukaryotic linear motif resourceNovel redox-dependent regulation of NOX5 by the tyrosine kinase c-AblStructural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationRegulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contextsGleevec inhibits beta-amyloid production but not Notch cleavageThe growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABLActivation of tyrosine kinases by mutation of the gatekeeper threonineTargeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitorsA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainTargeting the SH2-Kinase Interface in Bcr-Abl Inhibits LeukemogenesisRole of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein KinaseMechanisms of drug resistance in kinases.Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activityDynamics-Driven Allostery in Protein KinasesMolecular dynamics and protein function.Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinasesRole of ABL family kinases in cancer: from leukaemia to solid tumoursA Src-like inactive conformation in the abl tyrosine kinase domainThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionIdentification of small molecules that disrupt signaling between ABL and its positive regulator RIN1Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase FunctionArg interacts with cortactin to promote adhesion-dependent cell edge protrusionN-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cellsTarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1Paralog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3-SH2-Tyrosine Kinase Protein Family.c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in SolutionCrk at the quarter century mark: perspectives in signaling and cancer.NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capIntramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membranePartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
A myristoyl/phosphotyrosine switch regulates c-Abl.
@en
type
label
A myristoyl/phosphotyrosine switch regulates c-Abl.
@en
prefLabel
A myristoyl/phosphotyrosine switch regulates c-Abl.
@en
P2093
P50
P1433
P1476
A myristoyl/phosphotyrosine switch regulates c-Abl.
@en
P2093
Bhushan Nagar
Jana Kretzschmar
John Kuriyan
P304
P356
10.1016/S0092-8674(03)00191-0
P407
P577
2003-03-01T00:00:00Z