Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation - Test2 - elhamkhani - TriplyDB

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

http://www.wikidata.org/entity/Q24648477

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Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1 ABL tyrosine kinases: evolution of function, regulation, and specificity Regulation of Ack1 localization and activity by the amino-terminal SAM domain Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site Evolution of SH2 domains and phosphotyrosine signalling networks Ten things you should know about protein kinases: IUPHAR Review 14 The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor Comparative surface geometry of the protein kinase family A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells Protein sectors: evolutionary units of three-dimensional structure Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions A comparison of protein kinases inhibitor screening methods using both enzymatic activity and binding affinity determination The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.Defying c-Abl signaling circuits through small allosteric compounds.NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.A dynamic view of domain-motif interactions.The regulation of N-methyl-D-aspartate receptors by Src kinase.Protein kinases: evolution of dynamic regulatory proteins Characterization of neuronal Src kinase purified from a bacterial expression system.BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib.Identification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases.Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.Insights into protein kinase regulation and inhibition by large scale structural comparison Conformational disturbance in Abl kinase upon mutation and deregulation.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Protein post-translational modifications: In silico prediction tools and molecular modeling.

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P2860

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

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2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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Benjamin E Turk

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Michael Kofler

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The genome of the social amoeba Dictyostelium discoideum

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture

Structural basis of membrane invagination by F-BAR domains.

Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713)

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases

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Panagis Filippakopoulos

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Giulio Superti-Furga

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