Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
about
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoterMultiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcriptionmTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availabilityThe RNA polymerase I transcription machineryRNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factorCondensed mitotic chromatin is accessible to transcription factors and chromatin structural proteinsNucleolus: the fascinating nuclear bodyBasic mechanisms in RNA polymerase I transcription of the ribosomal RNA genesMolecular basis of Rrn3-regulated RNA polymerase I initiation and cell growthNuclear export modulates the cytoplasmic Sir2 homologue Hst2.DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA productionIn exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes.Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.Nucleolar dominance and ribosomal RNA gene silencingSelective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.Regulation of ribosomal RNA production by RNA polymerase I: does elongation come first?rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switchRNA-polymerase-I-directed rDNA transcription, life and works.Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway.Modulation of RNA polymerase assembly dynamics in transcriptional regulation.Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling.Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiaeRegulation of ribosomal gene expression in cancer.TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis.Identification of EhTIF-IA: The putative E. histolytica orthologue of the human ribosomal RNA transcription initiation factor-IA.Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.Rrn3 becomes inactivated in the process of ribosomal DNA transcription.Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49.The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.Regulation of the association of the PAF53/PAF49 heterodimer with RNA polymerase IPhotocross-linking of the RNA polymerase I preinitiation and immediate postinitiation complexes: implications for promoter recruitment.PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression.
P2860
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P2860
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
@en
type
label
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
@en
prefLabel
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
@en
P2093
P2860
P356
P1476
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
@en
P2093
Alice H Cavanaugh
Iwona Hirschler-Laszkiewicz
Lawrence I Rothblum
Miroslav Dundr
Tom Misteli
P2860
P304
27423-27432
P356
10.1074/JBC.M201232200
P407
P577
2002-05-15T00:00:00Z