mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
about
The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cellsRequirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cellsPIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcriptionSignaling by target of rapamycin proteins in cell growth controlPTEN represses RNA Polymerase I transcription by disrupting the SL1 complexActivation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)S6K1 plays a critical role in early adipocyte differentiationProtein kinases and phosphatases in the control of cell fatemTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availabilityThe mTOR signalling pathway in human cancerAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyThe RNA polymerase I transcription machinerymTOR: from growth signal integration to cancer, diabetes and ageingLive strong and prosper: the importance of skeletal muscle strength for healthy ageingThe role of the ribosome in the regulation of longevity and lifespan extensionRoles of mTOR Signaling in Brain DevelopmentBasic mechanisms in RNA polymerase I transcription of the ribosomal RNA genesNuclear PI3K signaling in cell growth and tumorigenesisPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsEmerging roles of the neuronal nucleolusmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsTIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growthTOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA productionHmo1 is required for TOR-dependent regulation of ribosomal protein gene transcriptionmTOR inhibitors in cancer therapyLeft-right asymmetry in the light of TOR: An update on what we know so farARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathwayThe physiology and pathophysiology of rapamycin resistance: implications for cancerRibosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cellsInhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway.Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in DrosophilaMammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle.Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disordersNuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis.The coordinate regulation of the p53 and mTOR pathways in cells.New frontiers in translational control of the cancer genomeAcetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF)
P2860
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P2860
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@ast
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@en
type
label
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@ast
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@en
prefLabel
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@ast
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@en
P2093
P2860
P1476
mTOR-dependent regulation of r ...... olar transcription factor UBF.
@en
P2093
Alice Cavanaugh
Anna Jenkins
Grant A McArthur
Katherine M Hannan
Kerith Sharkey
Lawrence Rothblum
Ross D Hannan
Yves Brandenburger
P2860
P304
P356
10.1128/MCB.23.23.8862-8877.2003
P407
P577
2003-12-01T00:00:00Z