Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.
about
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane eventsA unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell linesQuercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cellsThe role of Ca2+ in the pathophysiology of pancreatitiscAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)Action potentials and insulin secretion: new insights into the role of Kv channels.Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granulesMouse mast cell secretory granules can function as intracellular ionic oscillators.Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cellsImpaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null miceCaV2.3 calcium channels control second-phase insulin releasePancreatic beta cells require NeuroD to achieve and maintain functional maturitySubplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretionMultivesicular exocytosis in rat pancreatic beta cells.Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.Cell polarity defines three distinct domains in pancreatic β-cells.Multiple kinetic components and the Ca2+ requirements of exocytosisMitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptorEffects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cellsCalmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin.The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic isletsSynapsins I and II are not required for β-cell insulin secretion: granules must pool their own weight.Multiple exocytotic pathways in pancreatic beta cells.Exocytotic insertion of calcium channels constrains compensatory endocytosis to sites of exocytosis.Sequential exocytosis of insulin granules is associated with redistribution of SNAP25The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoproteinActivation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cellsProtein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cellsInsulin granule biogenesis, trafficking and exocytosis.Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.Insulin secretion from beta cells within intact islets: location matters.
P2860
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P2860
Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Co-localization of L-type Ca2+ ...... s in mouse pancreatic B-cells.
@en
type
label
Co-localization of L-type Ca2+ ...... s in mouse pancreatic B-cells.
@en
prefLabel
Co-localization of L-type Ca2+ ...... s in mouse pancreatic B-cells.
@en
P2093
P2860
P1433
P1476
Co-localization of L-type Ca2+ ...... s in mouse pancreatic B-cells.
@en
P2093
P2860
P407
P577
1995-01-01T00:00:00Z