Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
about
beta-Amyloid degradation and Alzheimer's diseaseAcyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptideThe Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell proteinAn aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrilsAluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque depositionMechanisms of Aβ Clearance and Degradation by Glial CellsDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsCerebrovascular disease in ageing and Alzheimer's diseaseClearance systems in the brain-implications for Alzheimer diseaseEndothelin-converting enzymes and related metalloproteases in Alzheimer's diseaseAlzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzymeEndothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12The ubiquitin-proteasome system in Alzheimer's diseaseβ-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide AMutation of active site residues of insulin-degrading enzyme alters allosteric interactionsCystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Alzheimer disease models and human neuropathology: similarities and differencesCerebrovascular reactivity to carbon dioxide in Alzheimer's disease.Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's diseaseDifferential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells.Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitroTransgenic Drosophila models of Alzheimer's disease and tauopathiesMultifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative DisordersKnockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cellsProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activityGinsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease.Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice.Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β proteinThe endocytic pathway in microglia during health, aging and Alzheimer's disease.Identification of BACE2 as an avid ß-amyloid-degrading protease
P2860
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P2860
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
@en
type
label
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
@en
prefLabel
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
@en
P2093
P2860
P356
P1476
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
@en
P2093
P2860
P304
24540-24548
P356
10.1074/JBC.M007579200
P407
P577
2001-05-03T00:00:00Z