The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
about
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyA dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivoSubstrate-mediated regulation of cullin neddylationThe NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrateUbiquitin-like protein activation.Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products.DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth
P2860
Q24522556-B700A60B-2E6E-4336-999F-A2B9DE3FCABFQ24554289-D7474DD7-17BF-4366-8A94-4248A19145D1Q27003218-93696A45-3657-49A1-AE16-A5616590E7E7Q28145252-E86C7113-BD89-4576-B644-6BC1227A53F9Q28298285-6C1B6F19-DD12-4B40-99C1-0515192538E7Q34202686-29C482C7-A751-4044-BFA4-2DA33394EDE0Q34984389-7CF12EBC-EC7C-4B15-984D-1DB0BF214404Q35691524-0FDD1DB5-BA59-4927-940E-F785352E6BACQ37230912-29B1E43D-0374-4418-95A1-B9C56DE5753BQ39196067-33DD1C8E-E5A8-4043-B478-A66781701C56Q40430046-98EA223E-8F0A-41C1-9B71-23E64BC96CA2Q58323648-06FA49DE-4594-4A69-A187-DACA6791628F
P2860
The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The von Hippel-Lindau tumor su ...... NEDD8 conjugation to cullin-2.
@en
type
label
The von Hippel-Lindau tumor su ...... NEDD8 conjugation to cullin-2.
@en
prefLabel
The von Hippel-Lindau tumor su ...... NEDD8 conjugation to cullin-2.
@en
P2093
P2860
P356
P1476
The von Hippel-Lindau tumor su ...... NEDD8 conjugation to cullin-2.
@en
P2093
P2860
P304
36025-36029
P356
10.1074/JBC.274.50.36025
P407
P577
1999-12-01T00:00:00Z