GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
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Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein familyA Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.Identification and characterization of essential genes in the human genome.Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader.Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germlineTissue homogeneity requires inhibition of unequal gene silencing during development.The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.Position-effect variegation revisited: HUSHing up heterochromatin in human cells.Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.Crosstalk between epigenetics and metabolism-Yin and Yang of histone demethylases and methyltransferases in cancer.The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals.ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH ComplexDigoxin reveals a functional connection between HIV-1 integration preference and T-cell activation.Characterization of a core region in the A2UCOE that confers effective anti-silencing activity.Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.Ten principles of heterochromatin formation and function.H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes.Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.MORC2B is essential for meiotic progression and fertility.Click chemistry enables preclinical evaluation of targeted epigenetic therapies.Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.New tools for old drugs: Functional genetic screens to optimize current chemotherapy.Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution.GENE REGULATION. A HUSH for transgene expression.MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.Epigenetic control of variation and stochasticity in metabolic disease.
P2860
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P2860
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
GENE SILENCING. Epigenetic sil ...... ct variegation in human cells.
@en
type
label
GENE SILENCING. Epigenetic sil ...... ct variegation in human cells.
@en
prefLabel
GENE SILENCING. Epigenetic sil ...... ct variegation in human cells.
@en
P2093
P2860
P50
P921
P356
P1433
P1476
GENE SILENCING. Epigenetic sil ...... ect variegation in human cells
@en
P2093
Gordon Dougan
Richard T Timms
Robin Antrobus
P2860
P304
P356
10.1126/SCIENCE.AAA7227
P407
P5008
P577
2015-05-28T00:00:00Z