Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.
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Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingA Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination ActivitiesOn Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in ProteasesStructure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligasesDeletion of ubiquitin fold modifier protein Ufm1 processing peptidase Ufsp in L. donovani abolishes Ufm1 processing and alters pathogenesisProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationSite-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiersStrategies for discovering and derisking covalent, irreversible enzyme inhibitors.Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes.Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probesCovalent Tethering of Fragments For Covalent Probe DiscoveryChemical Methods for Encoding and Decoding of Posttranslational ModificationsUnraveling the complexity of ubiquitin signalingActivity-based probes: discovering new biology and new drug targets.Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection.Chemistry and biology of the ubiquitin signal.Recent advances in quantitative and chemical proteomics for autophagy studies.Chemical and semisynthetic approaches to study and target deubiquitinases.Activity-Based Probes for HECT E3 Ubiquitin LigasesA native chemical ligation handle that enables the synthesis of advanced activity-based probes: diubiquitin as a case study.Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes.Site-specific N-terminal labeling of proteins using sortase-mediated reactions.Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymesNew semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin.Selenocysteine as a latent bioorthogonal electrophilic probe for deubiquitylating enzymes.UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis.Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.Fluorescence-based active site probes for profiling deubiquitinating enzymesGetting a chemical handle on proteinpost-translational modification
P2860
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P2860
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@en
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@nl
type
label
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@en
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@nl
prefLabel
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@en
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@nl
P2093
P2860
P356
P1433
P1476
Ubiquitin C-terminal electroph ...... iquitin conjugating machinery.
@en
P2093
Eric Spooner
Hidde L Ploegh
Kerry Routenberg Love
Renuka K Pandya
P2860
P304
P356
10.1021/CB9000348
P577
2009-04-01T00:00:00Z