Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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Not just amyloid: physiological functions of the amyloid precursor protein family.Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

P2860

Q39209681-7AD5533A-CB99-480B-8E77-F1B19E1DABB5 Q47149447-61CCDF05-3A04-473C-B8D4-BCAA37B30837

P2860

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

@en

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

@en

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

@nl

P1476

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

@en

P2093

Karima Bettayeb

http://www.w3.org/2001/XMLSchema#string

Subhash C Sinha

http://www.w3.org/2001/XMLSchema#string

Victor Bustos

http://www.w3.org/2001/XMLSchema#string

William J Netzer

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

Gleevec inhibits beta-amyloid production but not Notch cleavage

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

Identification of beta-secretase (BACE1) substrates using quantitative proteomics.

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1389-1394

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scholarly article

P356

10.1073/PNAS.1620963114

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

114

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P50

Paul Greengard

Marc Flajolet

P577

2017-01-23T00:00:00Z

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P698

28115709

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P932

5307477

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

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P2860

P2860

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932