about
Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignanciesAcute myeloid leukaemia: a paradigm for the clonal evolution of cancer?A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesisL3mbtl, the mouse orthologue of the imprinted L3MBTL, displays a complex pattern of alternative splicing and escapes genomic imprintingManagement of the myeloproliferative disorders : distinguishing data from dogma.Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.Capturing needles in haystacks: a comparison of B-cell receptor sequencing methods.Origins and functional consequences of somatic mitochondrial DNA mutations in human cancerA novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.Effect of mutation order on myeloproliferative neoplasms.Enhancing the genome editing toolbox: genome wide CRISPR arrayed librariesCharacterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocolStella-Cre mice are highly efficient Cre deleters.Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populationsGene expression changes in HLA mismatched mixed lymphocyte cultures reveal genes associated with allorecognition.New approaches for modelling sporadic genetic disease in the mouseHistone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones.The role of high-throughput technologies in clinical cancer genomics.Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.Calreticulin mutations in myeloproliferative neoplasms and new methodology for their detection and monitoring.Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemiaTargeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.Aging as a driver of leukemogenesis.Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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type
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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prefLabel
George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
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George S Vassiliou
@sl
P106
P21
P31
P496
0000-0003-4337-8022