Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation.
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The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activityActivation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascadeTankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosisFrom estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosisCoordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability.Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression.Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.Degeneration of the mouse retina upon dysregulated activity of serum response factor.Ets target genes: past, present and future.EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factorsPreclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1.Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regenerationRegulation of Mcl-1 by constitutive activation of NF-κB contributes to cell viability in human esophageal squamous cell carcinoma cells.Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancerVinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosisELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanismsThe Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations.MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complexDown-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo.Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors.Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.Upregulation of SRF Is Associated With Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl-2.Phospho-Ser383-Elk-1 is localized to the mitotic spindles during cell cycle and interacts with mitotic kinase Aurora-A.Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.PIASx acts as an Elk-1 coactivator by facilitating derepression.Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway.Overlapping promoter targeting by Elk-1 and other divergent ETS-domain transcription factor family membersDifferential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway.p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter.SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development.Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells.Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis.
P2860
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P2860
Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@en
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@nl
type
label
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@en
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@nl
prefLabel
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@en
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@nl
P2093
P2860
P356
P1476
Regulation of MCL1 through a s ...... opoietic cell differentiation.
@en
P2093
C H Lowrey
C K Bieszczad
K J Townsend
P2860
P304
P356
10.1074/JBC.274.3.1801
P407
P577
1999-01-01T00:00:00Z