Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. - Test2 - elhamkhani - TriplyDB

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds.

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds.

http://www.wikidata.org/entity/Q42540715

about

Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization Thioredoxin reductase Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents The redox biology of schistosome parasites and applications for drug development Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition TrxR1 as a potent regulator of the Nrf2-Keap1 response system Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water Gold compounds as therapeutic agents for human diseases Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents Auranofin increases apoptosis and ischaemia-reperfusion injury in the rat isolated heart Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets.Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis Identification of New Antifungal Compounds Targeting Thioredoxin Reductase of Paracoccidioides Genus Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activation Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine Extracellular conversion of adiponectin hexamers into trimers Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis The functional role of selenocysteine (Sec) in the catalysis mechanism of large thioredoxin reductases: proposition of a swapping catalytic triad including a Sec-His-Glu state.Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles.In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles.Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species.News and views on thioredoxin reductases.The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.

P2860

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P2860

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds.

http://www.wikidata.org/entity/Q42540715

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

@zh-tw

1998年论文

@wuu

1998年论文

@zh

1998年论文

@zh-cn

name

Human placenta thioredoxin red ...... by therapeutic gold compounds.

@en

Human placenta thioredoxin red ...... by therapeutic gold compounds.

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type

label

Human placenta thioredoxin red ...... by therapeutic gold compounds.

@en

Human placenta thioredoxin red ...... by therapeutic gold compounds.

@nl

prefLabel

Human placenta thioredoxin red ...... by therapeutic gold compounds.

@en

Human placenta thioredoxin red ...... by therapeutic gold compounds.

@nl

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Journal of Biological Chemistry

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Human placenta thioredoxin red ...... by therapeutic gold compounds.

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Arscott LD

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Becker K

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Gromer S

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Schirmer RH

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Williams CH Jr

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P2860

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

Type I iodothyronine deiodinase is a selenocysteine-containing enzyme

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2

Cloning and sequencing of a human thioredoxin reductase.

Generating compatible translation initiation regions for heterologous gene expression in Escherichia coli by exhaustive periShine-Dalgarno mutagenesis. Human glutathione reductase cDNA as a model.

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

Interaction of gold(I) with the active site of selenium-glutathione peroxidase.

Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone.

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20096-20101

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