about
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body productionThe Enzyme Function Initiative.Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screeningLeveraging structure for enzyme function prediction: methods, opportunities, and challengesA new coarse-grained model for E. coli cytoplasm: accurate calculation of the diffusion coefficient of proteins and observation of anomalous diffusionDefining the Product Chemical Space of Monoterpenoid SynthasesModeling conformational ensembles of slow functional motions in Pin1-WWPrediction and assignment of function for a divergent N-succinyl amino acid racemaseRescoring Docking Hit Lists for Model Cavity Sites: Predictions and Experimental TestingComputation-Facilitated Assignment of the Function in the Enolase Superfamily: A Regiochemically Distinct Galactarate Dehydratase from Oceanobacillus iheyensis ,Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and FluconazoleTurning a protein kinase on or off from a single allosteric site via disulfide trapping.Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamilyHomology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamilyStructure-guided discovery of the metabolite carboxy-SAM that modulates tRNA functionActive Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2Discovery of new enzymes and metabolic pathways by using structure and genome contextQuantifying Correlations Between Allosteric Sites in Thermodynamic EnsemblesConformational changes in protein loops and helices induced by post-translational phosphorylation.Binding-site assessment by virtual fragment screeningPhosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activationPredicting binding to p-glycoprotein by flexible receptor dockingEvolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58The free energy profile of tubulin straight-bent conformational changes, with implications for microtubule assembly and drug discoveryA structure-based model for predicting serum albumin bindingDisulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide bindingSIRT5 regulates the mitochondrial lysine succinylome and metabolic networksOutcome of a workshop on applications of protein models in biomedical researchVirtual screening against highly charged active sites: identifying substrates of alpha-beta barrel enzymes.Complete protein structure determination using backbone residual dipolar couplings and sidechain rotamer prediction.Computational modeling of the catalytic reaction in triosephosphate isomerase.Novel procedure for modeling ligand/receptor induced fit effects.Assignment of polar states for protein amino acid residues using an interaction cluster decomposition algorithm and its application to high resolution protein structure modeling.Computational studies of protein regulation by post-translational phosphorylation.Assessment of the protein-structure refinement category in CASP8Non-degradative Ubiquitination of Protein Kinases.Assessment of protein structure refinement in CASP9.Considering protonation as a posttranslational modification regulating protein structure and function.Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.
P50
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P50
description
hulumtues
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researcher
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հետազոտող
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name
Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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type
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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Matthew P. Jacobson
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P106
P1153
7402311012
P21
P2456
P31
P496
0000-0001-6262-655X