Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
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GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synucleinGSK3beta in ethanol neurotoxicityGSK-3beta is required for memory reconsolidation in adult brainNFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapyGSK-3: Functional Insights from Cell Biology and Animal Models.GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animalsTau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion proteinA DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.Why pleiotropic interventions are needed for Alzheimer's disease.Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent mannerNeuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependentAmyloid-beta induced CA1 pyramidal cell loss in young adult rats is alleviated by systemic treatment with FGL, a neural cell adhesion molecule-derived mimetic peptide.The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway.Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patientsGSK3β expression and phosphorylation during neuronal maturation in the rat dorsal root ganglion.Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine MorphologyFunctional implications of glycogen synthase kinase-3-mediated tau phosphorylationGSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.GSK-3β, a pivotal kinase in Alzheimer disease.Lithium suppression of tau induces brain iron accumulation and neurodegeneration.Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation.GSK3β Controls mTOR and Prosurvival Signaling in Neurons.Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3β in the striatum of rats treated with 3-nitropropionic acid.Lithium stimulates human bone marrow derived mesenchymal stem cell proliferation through GSK-3β-dependent β-catenin/Wnt pathway activation.Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus
P2860
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P2860
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@en
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@nl
type
label
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@en
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@nl
prefLabel
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@en
Neuronal apoptosis and reversi ...... 3 conditional transgenic mice.
@nl
P2093
P2860
P50
P356
P1433
P1476
Neuronal apoptosis and reversi ...... -3 conditional transgenic mice
@en
P2093
Francesc Artigas
Jean Pierre Gotteland
Jesús Avila
Paola Zaratin
Raquel Gómez-Sintes
P2860
P304
P356
10.1038/SJ.EMBOJ.7601725
P407
P577
2007-05-17T00:00:00Z