Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
about
Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptorSubstitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingPresenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylationGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsThe MAP2/Tau family of microtubule-associated proteinsThe dynamic role of beta-catenin in synaptic plasticity(-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat ModelToxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninPresenilin 1 protein directly interacts with Bcl-2GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptidesPresenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashionThe ups and downs of Wnt signaling in prevalent neurological disordersMice lacking both presenilin genes exhibit early embryonic patterning defectsForebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrilsPS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsPresenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1WNT and beta-catenin signalling: diseases and therapiesTau-mediated neurodegeneration in Alzheimer's disease and related disordersAmyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.Altered binding of mutated presenilin with cytoskeleton-interacting proteins.Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice.Apolipoprotein E: a major piece in the Alzheimer's disease puzzle.A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling.Roles of tau protein in health and disease.Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilinBiology of presenilins as causative molecules for Alzheimer disease.Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice.Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.Studying human neurodegenerative diseases in flies and worms.Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard catsDecreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic miceThe JNK/c-Jun cascade and Alzheimer's disease.Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling.
P2860
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P2860
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@ast
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en-gb
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@nl
type
label
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@ast
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en-gb
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@nl
prefLabel
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@ast
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en-gb
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@nl
P2093
P2860
P3181
P356
P1476
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
@en
P2093
A Takashima
H Yamaguchi
K Yasutake
M Murayama
N Nihonmatsu
O Murayama
S Sugihara
P2860
P304
P3181
P356
10.1073/PNAS.95.16.9637
P407
P577
1998-08-04T00:00:00Z