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On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cellsMechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulationCholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retinaInvolvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterasesStudies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterolStudies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axesOn the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.Oxysterols: friends, foes, or just fellow passengers?High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondriaOxysterols and Alzheimer's disease.miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 inductionOn the formation and possible biological role of 25-hydroxycholesterol.Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophagesEffects of high-dose itraconazole treatment on lipoproteins in men.Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.Metabolism of 4 beta -hydroxycholesterol in humans.Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols.Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans.Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products.On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions.Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment.4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients.
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P50
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Ulf Diczfalusy
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Ulf Diczfalusy
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Ulf Diczfalusy
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Ulf Diczfalusy
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Ulf Diczfalusy
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Ulf Diczfalusy
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P106
P21
P31
P496
0000-0001-6643-3763