Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. - Test2 - elhamkhani - TriplyDB

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

http://www.wikidata.org/entity/Q42914749

about

Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcripts Modulating splicing with small molecular inhibitors of the spliceosome The organization and contribution of helicases to RNA splicing Functional roles of DExD/H-box RNA helicases in Pre-mRNA splicing RNA-Binding Proteins: Splicing Factors and Disease RNA helicases in splicing Splicing fidelity: DEAD/H-box ATPases as molecular clocks RNA helicase proteins as chaperones and remodelers Structural model of the p14/SF3b155{middle dot}branch duplex complex Structure and assembly of the SF3a splicing factor complex of U2 snRNP Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1.Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway.Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density maps Single-Molecule Pull-Down FRET to Dissect the Mechanisms of Biomolecular Machines RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing.SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.Rearrangements within human spliceosomes captured after exon ligation.DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps.Structural requirement of Ntc77 for spliceosome activation and first catalytic step.Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions.GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo.Roles of DEAD-box proteins in RNA and RNP Folding.RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts Dramatically reduced spliceosome in Cyanidioschyzon merolae Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.A U1-U2 snRNP interaction network during intron definition ATPγS stalls splicing after B complex formation but prior to spliceosome activation.Functional roles of protein splicing factors.

P2860

Q21134031-C6CC5E10-AA4B-45F1-A742-2DBFC9DAA7DF Q26738664-6D9C684E-ABA9-4EB2-9CF0-441EE059355D Q26766200-E3954BCD-42BB-44B0-AE52-99F6686268E4 Q26801902-5C9217B3-7A69-4F83-BFEA-CB845CDD3BAB Q26823957-16A45ED5-9E07-4DE1-978D-F994AFAAB90E Q27000261-A75CEBF9-0812-4055-A668-6E6D7B838632 Q27008926-53FF3753-EB36-40A7-A935-08405C9F4899 Q27025517-4AD4C822-913D-493D-A523-AF6854F7D599 Q27665723-BFA5F532-DCCF-4B7A-9D9D-6E4451F1FD4E Q27677135-02EB2245-1BD3-44BD-AF52-17AACD6C8531 Q27929798-0A9E6CDD-EEB1-47C3-92DB-29436F2D44B9 Q27932730-020A3B42-6992-46BA-85B0-E1BFE23686C4 Q27933083-B6E3DEF0-8B55-411D-BBBE-3DD2184F3644 Q27935431-B4EACC6B-6949-4536-B767-3FB545C6E10C Q27937892-FB4C81B8-E028-418C-A06E-51C006587801 Q27938864-19B9BBC6-F50D-4881-8099-329C312C629E Q27939472-CB14CD4F-6A8D-4AE5-BBF4-7384B3C32D51 Q27939740-67A1B31A-C250-494F-8220-6078F39F7903 Q28114993-DA3FBF40-C72E-443B-8279-8035BC4EFEF7 Q28315106-AB5C9D8A-A877-4C50-AC1F-B72E157E0EA9 Q28601989-E71AB486-6842-4C1B-905B-282993F0A838 Q30556912-F064E348-9BE0-4EE3-8202-3C6DCCDD3BD8 Q30559916-8E850C40-7206-437D-93AB-94D28153BC95 Q33635951-CF4E86D1-FCAD-44E1-B590-F0D02DEDD898 Q33867447-F838B1A8-A639-412C-9EDB-CE59B4C796D6 Q33883523-31A345A6-D247-4247-B6F2-E3AA9C242109 Q34146146-BAE990BF-1B58-4D5B-BE30-29D1AF231800 Q34324094-0B8B5E7A-4D45-4383-B808-4EF316B39E3D Q34415414-9D35585E-16ED-4D34-BCD6-ABA78D8A4C02 Q34510168-B3B96059-1E35-41D4-B24D-37D8C9C32D36 Q34518971-9D6EFA80-A4DF-44B4-B735-A238A88076ED Q34700379-21574FB6-4603-45A9-8923-4B10C7EE8631 Q34706824-6989B65C-DD9C-4F15-9103-4E77FE4EE803 Q34775640-95EFECBF-C5F4-471E-A51E-C8D9FC37B1DA Q34946799-F7D73B71-EBFD-4D72-B7F6-F2B7CB4CF003 Q35212551-CA118CDB-BDEB-4573-B091-E40F10145AAB Q35276828-3EBC762A-BE62-4869-A5A7-F730EB1A500C Q35665670-1894959A-E859-4993-A4A4-C1B90A892A43 Q36076436-24D45073-6F04-4951-ADF7-866F23B3A645 Q36083004-13DED690-3608-4F88-9B25-71F58F509412

P2860

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

http://www.wikidata.org/entity/Q42914749

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@en

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@nl

type

label

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@en

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@nl

prefLabel

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@en

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@nl

P1433

Q42914749-9C8A07CC-E07E-4935-AE0D-AEE1B131DA64

P1476

Q42914749-B158488E-332A-48DC-8EEC-725BB409CC25

P2093

Q42914749-8A436934-F516-4F05-BCF2-57E2853B7243

Q42914749-8CED0C06-51BA-484D-8C82-85C521175E01

Q42914749-BE4C6001-9FBE-4884-8CF4-41A7F8A1DD29

Q42914749-E5C8D615-F8FC-4E76-B5D6-1163CB89ACF6

P2860

Q42914749-030A1480-0BB7-4E67-8A78-AA4699CA881C

Q42914749-06A2EC20-D644-405B-9413-FA09C847B2CC

Q42914749-08110607-686B-4894-8661-087FBA367990

Q42914749-0D39F9A8-6BA4-46A1-84ED-527EA22C6AF3

Q42914749-0FDB80C1-A23C-46A8-B4D0-6575D0BEF203

Q42914749-11C9A70C-9A68-4BFD-BB5A-3D3359C208D3

Q42914749-1A761EE9-7687-4A11-B936-4879C4859B7D

Q42914749-1D983EBA-564C-4A51-B855-7B563163761A

Q42914749-1F4F86D9-8CB2-4FF4-BC3C-038884806905

Q42914749-2073A231-CA1A-47E7-9004-8D70A0A68952

P304

Q42914749-2195154A-4279-41E9-99FA-263BDEAC2AC1

P31

Q42914749-77E9B3E9-186B-413F-9E6A-67A7471861A9

P356

Q42914749-83DF35E3-7769-42AB-B5F3-0BAB47C43F1C

P407

Q42914749-70069756-3281-4B08-A27B-D13CB1A98E48

P433

Q42914749-A849A2EE-90C0-46AA-9464-32BB20E74ABC

P478

Q42914749-18C2021D-5F8E-4D5B-AC2E-CECF658130FE

P577

Q42914749-7A20B670-B946-482F-89E5-0BFD951F99AB

P5875

Q42914749-49C057AF-E7CB-471D-B93F-06988A47DC09

P698

Q42914749-8E2DE4DF-6247-4885-AB12-C55FD570373C

P932

Q42914749-50B362F4-F15F-48C0-9E95-88D2083953F1

P356

P1433

P1476

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

@en

P2093

James X Thompson

http://www.w3.org/2001/XMLSchema#string

John R Yates

http://www.w3.org/2001/XMLSchema#string

Rea M Lardelli

http://www.w3.org/2001/XMLSchema#string

Scott W Stevens

http://www.w3.org/2001/XMLSchema#string

P2860

A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein

Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly

Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing

Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae

The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors

P304

516-528

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1261/RNA.2030510

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

16

http://www.w3.org/2001/XMLSchema#string

P577

2010-01-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

41102057

http://www.w3.org/2001/XMLSchema#string

P698

20089683

http://www.w3.org/2001/XMLSchema#string

P932

2822917

http://www.w3.org/2001/XMLSchema#string