MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
about
Synthetic lethal screens as a means to understand and treat MYC-driven cancersMYC and the control of DNA replication.RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cellsA PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth.MYC is a critical target of FBXW7Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel BiomarkersDNA helicases involved in DNA repair and their roles in cancerFunctional genomics identifies therapeutic targets for MYC-driven cancer.Human RecQ helicases in DNA repair, recombination, and replication.Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Cdc45 is a critical effector of myc-dependent DNA replication stress.WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance.MYC oncogene in myeloid neoplasias.Structural mechanisms of human RecQ helicases WRN and BLM.Management of knee osteoarthritis. Current status and future trends.The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.c-MYC-induced genomic instability.Functional genomics to identify unforeseen cancer drug targets.Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
P2860
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P2860
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@en
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@nl
type
label
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@en
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@nl
prefLabel
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@en
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@nl
P2093
P2860
P1476
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
@en
P2093
Carla Grandori
Christopher J Kemp
Heather L Howie
Jerry Davison
Kay E Gurley
Kristin Robinson
Martin Morgan
Masafumi Toyoshima
Russell Moser
P2860
P304
P356
10.1158/1541-7786.MCR-11-0508
P577
2012-02-01T00:00:00Z