MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency. - Test2 - elhamkhani - TriplyDB

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

http://www.wikidata.org/entity/Q43097729

about

Synthetic lethal screens as a means to understand and treat MYC-driven cancers MYC and the control of DNA replication.RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth.MYC is a critical target of FBXW7 Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers DNA helicases involved in DNA repair and their roles in cancer Functional genomics identifies therapeutic targets for MYC-driven cancer.Human RecQ helicases in DNA repair, recombination, and replication.Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Cdc45 is a critical effector of myc-dependent DNA replication stress.WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance.MYC oncogene in myeloid neoplasias.Structural mechanisms of human RecQ helicases WRN and BLM.Management of knee osteoarthritis. Current status and future trends.The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.c-MYC-induced genomic instability.Functional genomics to identify unforeseen cancer drug targets.Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

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P2860

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

http://www.wikidata.org/entity/Q43097729

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh-hant

name

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@en

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@nl

type

label

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@en

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@nl

prefLabel

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@en

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@nl

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1541-7786.MCR-11-0508

P1433

Molecular Cancer Research

P1476

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

@en

P2093

Carla Grandori

http://www.w3.org/2001/XMLSchema#string

Christopher J Kemp

http://www.w3.org/2001/XMLSchema#string

Heather L Howie

http://www.w3.org/2001/XMLSchema#string

Jerry Davison

http://www.w3.org/2001/XMLSchema#string

Kay E Gurley

http://www.w3.org/2001/XMLSchema#string

Kristin Robinson

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Martin Morgan

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Masafumi Toyoshima

http://www.w3.org/2001/XMLSchema#string

Russell Moser

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P2860

The Werner syndrome protein is a DNA helicase

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Roles of Werner syndrome protein in protection of genome integrity

c-Myc accelerates S-phase and requires WRN to avoid replication stress

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

CDK inhibitors: positive and negative regulators of G1-phase progression

Non-transcriptional control of DNA replication by c-Myc

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

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535-545

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10.1158/1541-7786.MCR-11-0508

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3707802

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