about
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for RacP-Rex2, a new guanine-nucleotide exchange factor for RacP-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironmentsRegulation and function of P-Rex family Rac-GEFsP-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responsesCa2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinaseP-Rex1 is required for efficient melanoblast migration and melanoma metastasis.Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.Purification of P-Rex1 from neutrophils and nucleotide exchange assay.Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.Phosphoinositide 3-kinase-dependent activation of Rac.Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets.PI3K and RAC signalling in leukocyte and cancer cell migration.The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissuesSignalling via phosphoinositide 3OH kinases.P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.A Rac1-independent role for P-Rex1 in melanoblasts.Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cellsHck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human GranulocytesNonreceptor Protein-Tyrosine Kinases in Neutrophil ActivationIntegrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawlingPI 3-kinaseRac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Heidi Welch
@ast
Heidi Welch
@en
Heidi Welch
@es
Heidi Welch
@nl
Heidi Welch
@sl
type
label
Heidi Welch
@ast
Heidi Welch
@en
Heidi Welch
@es
Heidi Welch
@nl
Heidi Welch
@sl
prefLabel
Heidi Welch
@ast
Heidi Welch
@en
Heidi Welch
@es
Heidi Welch
@nl
Heidi Welch
@sl
P106
P21
P31
P496
0000-0001-7865-7000