Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings.
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hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismProteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination.Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cellsThe caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation.Role of proteasomes in disease.Control of mitochondrial biogenesis and function by the ubiquitin-proteasome systemParkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.Modelling proteasome and proteasome regulator activities.ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome.Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsFlexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal.Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entryGeneration of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomesAging perturbs 26S proteasome assembly in Drosophila melanogasterThe ubiquitin-proteasome system in Huntington's disease.Highbrow proteasome in high-throughput technology.The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart.Effects of an anticarcinogenic Bowman-Birk protease inhibitor on purified 20S proteasome and MCF-7 breast cancer cells.Oxidative protein damage and the proteasome.Context-dependent resistance to proteolysis of intrinsically disordered proteins.Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration.Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.Harnessing proteasome dynamics and allostery in drug design.Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination.Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex.Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.Establishment of a suite of assays that support the discovery of proteasome stimulators.Proteasome properties of hemocytes differ between the whiteleg shrimp Penaeus vannamei and the brown shrimp Crangon crangon (Crustacea, Decapoda).Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways.Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome.AAA-ATPases in Protein Degradation.Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sitesDirect proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation.A mathematical model of protein degradation by the proteasome.Intracellular peptides as natural regulators of cell signaling.Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.
P2860
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P2860
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@en
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@nl
type
label
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@en
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@nl
prefLabel
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@en
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@nl
P2093
P2860
P356
P1476
Binding of hydrophobic peptide ...... el opening in the alpha-rings.
@en
P2093
Alexei F Kisselev
Alfred L Goldberg
Daniel Kaganovich
P2860
P304
22260-22270
P356
10.1074/JBC.M112360200
P407
P577
2002-04-01T00:00:00Z