about
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1IPAF elicitors:NLRC4:Procaspase-1dsDNA:AIM2 oligomer:ASC:Procaspase-1CASP1(120-197):CASP1(317-404)TP53 family members stimulate CASP1 expressionThe CARD domain of ASC recruits Procaspase-1IPAF binds procaspase-1dsDNA:AIM2:ASC cluster binds procaspase-1Caspase-1 precursor is cleaved releasing p10 and p20 subunitsFormation of caspase-1 p10/p20 dimer
P527
P688
The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activationNucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activationDectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasomeThe inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaCaspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's diseaseNALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderAIM2 activates the inflammasome and cell death in response to cytoplasmic DNAAn orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeCDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegenerationMolecular cloning of the interleukin-1 beta converting enzymeUnified polymerization mechanism for the assembly of ASC-dependent inflammasomes.Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processingRegulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteinsINCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generationCARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
P921
Q50261486-44440E8F-63AC-4A97-8790-F19E0DC7F41AQ50261510-2CDCFA17-CFFE-4C54-AD21-DA3FA904525BQ50261514-F13A5082-3020-472E-BB52-189BC0EBD8C5Q50262623-1AF72342-7707-4B0E-99F1-3340D984FC58Q50290228-F1A82031-EAAC-4343-AF9E-7D6B3DA909DDQ50291983-2004A433-D725-49FB-9568-4747AC92D429Q50291995-F347B11D-5649-4624-BD43-E124FB8702B9Q50292000-FA29A203-A892-493B-A7E6-FCBF38141DEEQ50292481-2C190014-E85F-4C3E-A75A-43B00693B28BQ50292481-E4920898-42A4-4390-80CD-FF8251A9BF0FQ50292482-223CF4EF-20DE-4AB1-92B0-8F9DF9AA7885
P527
Q22254032-141CB7C9-AB61-4215-8928-4A46593A9D6FQ24301708-DA55493B-7461-4B55-870F-2FDC18816116Q24303046-D2026D47-2B99-476B-A3FC-A784E7735E83Q24305136-C1E0991E-7694-4791-A447-35A1B6271378Q24312611-E4479512-23E9-4C5C-84C7-299C558B89D9Q24317771-14957F2A-1037-47FF-B736-A8612F19401DQ24319765-EAABC2F3-9683-4ACD-BBA8-02472C7BC5C0Q24319799-984238B3-2962-4CF6-8DF8-3E323536ECF1Q24337541-E5033E84-955E-47EE-BA53-2C98D733775DQ24338607-71B79BE7-C7A8-4A61-B5C3-CB4138F020CDQ24339219-024BA0FB-8D45-4624-B653-CBF43C7BA2F2Q27310134-87789B58-607E-46A4-9DF8-C6C0F48984A3Q28204263-AA65C957-58C1-4E85-8D71-A7DCBE5251C8Q28215242-E697175F-E41E-45A5-BDF0-FBDBC17EED3AQ28283586-20E59D7F-9BF4-4758-BD6A-68C8F1EEC78DQ30668600-D4BBD9BE-7EC6-437E-BAB3-1CA7204D5F0FQ30981901-0A49789E-E249-4A88-B43F-97162FE6A849
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
Caspase 1
@en
Caspase 1
@fr
Caspase 1
@nl
Caspase 1
@pt
Kaspaza-1
@sh
Kaspaza-1
@sr
type
label
Caspase 1
@en
Caspase 1
@fr
Caspase 1
@nl
Caspase 1
@pt
Kaspaza-1
@sh
Kaspaza-1
@sr
altLabel
CASP1 nirs variant 1
@en
CASP1
@en
ICE
@en
IL-1 beta-converting enzyme
@en
IL-1BC
@en
IL1B-convertase
@en
Interleukin-1 beta convertase
@en
Interleukin-1 beta-converting enzyme
@en
caspase 1, apoptosis-related cysteine peptidase
@en
caspase-1
@en
prefLabel
Caspase 1
@en
Caspase 1
@fr
Caspase 1
@nl
Caspase 1
@pt
Kaspaza-1
@sh
Kaspaza-1
@sr
P637
P638
P680
P681
P682
P705
P352
P486
P637
P646
P6680
P6694
P231
122191-40-6
P2888
P31
P352
P486
P591
P637
NP_001244047
NP_001244048
XP_016873882
XP_016873883
XP_016873884
P638
P646
/m/02p9hc6
P6680
P6694
P680
P681
P682
P702
P703
P705
ENSP00000344132
ENSP00000403260
ENSP00000410076
ENSP00000431947
ENSP00000432340
ENSP00000433138
ENSP00000434250
ENSP00000434259
ENSP00000434303
ENSP00000434779