CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

P2860

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

Item

http://www.wikidata.org/entity/Q24337541

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2014 nî lūn-bûn

@nan

2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@ast

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en-gb

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@nl

type

Item

label

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@ast

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en-gb

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@nl

prefLabel

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@ast

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en-gb

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@nl

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P3181

232684

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JNC.12684

P1433

Journal of Neurochemistry

P1476

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

@en

P2093

Aaron Voigt

http://www.w3.org/2001/XMLSchema#string

Christoph P Dohm

http://www.w3.org/2001/XMLSchema#string

Hannes Voßfeldt

http://www.w3.org/2001/XMLSchema#string

Jan Liman

http://www.w3.org/2001/XMLSchema#string

Jochen Weishaupt

http://www.w3.org/2001/XMLSchema#string

Mathias Bähr

http://www.w3.org/2001/XMLSchema#string

Pawel Kermer

http://www.w3.org/2001/XMLSchema#string

Sebastian Deeg

http://www.w3.org/2001/XMLSchema#string

P2860

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

A survey of spinocerebellar ataxia in South Brazil - 66 new cases with Machado-Joseph disease, SCA7, SCA8, or unidentified disease-causing mutations.

Toxic proteins in neurodegenerative disease.

Role of proteolysis in polyglutamine disorders.

Machado-Joseph disease mutations as the genetic basis of most spinocerebellar ataxias in Germany

P304

1013-23

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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232684

http://www.w3.org/2001/XMLSchema#string

P356

10.1111/JNC.12684

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

129

http://www.w3.org/2001/XMLSchema#string

P50

André Karch

Jörg B Schulz

P577

2014-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

260251149

http://www.w3.org/2001/XMLSchema#string

P698

24548080

http://www.w3.org/2001/XMLSchema#string

P921

negative regulation of neuron death

Cyclin dependent kinase 5

Ataxin 3

Caspase 1